Search results for "Risk evaluation"
showing 8 items of 8 documents
Immunological and immunogenetic markers in sporadic Alzheimer’s disease
2006
Background: Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer''s disease (AD) have been shown to be associated with AD. Aims: The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed. Conclusion: The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.
Integrating the human factor in FMECA-based risk evaluation through Bayesian networks
2020
The contribution of the present paper aims to develop the traditional Failure Modes, Effects and Criticality Analysis (FMECA) for quantitative risk analysis from a Bayesian Network (BN)-based perspective. The main purpose of research consists in providing a framework for analysing causal relationships for risk evaluation and deriving probabilistic inference among significant risk factors. These parameters will be represented by linguistic variables and will include the human factor as a key element of analysis. Traditional approaches for risk evaluation and management performed by FMECA [1] represent helpful tools to globally enhance systems and processes conditions [2]. However, such appro…
Managing Human Factors to Reduce Organisational Risk in Industry
2018
[EN] Human factors are intrinsically involved at virtually any level of most industrial/business activities, and may be responsible for several accidents and incidents, if not correctly identified and managed. Focusing on the significance of human behaviour in industry, this article proposes a multi-criteria decision-making (MCDM)-based approach to support organizational risk assessment in industrial environments. The decision-making trial and evaluation laboratory (DEMATEL) method is proposed as a mathematical framework to evaluate mutual relationships within a set of human factors involved in industrial processes, with the aim of highlighting priorities of intervention. A case study relat…
A risk evaluation framework for the best maintenance strategy: the case of a marine salt manufacture firm
2020
Highlights • This paper proposes a MCDM framework to support risk evaluation for maintenance activities. • The ANP is proposed to select the best maintenance strategy on the basis of real systems’ features. • The ELECTRE III is used to prioritise the main risks related to the interventions of the selected maintenance policy. • The proposed framework is applied to a core subsystem of a real-world marine salt manufacture firm.
Frailty syndrome and pre-operative risk evaluation: A systematic review
2015
Abstract Background Frailty is a geriatric syndrome characterized by the clinical presentation of identifiable physical alterations and decreased physiological reserve. The assessment of frailty syndrome has been recently related with post-surgical outcomes and overall mortality in older individuals. Design and data sources We performed searches in Pubmed, Embase, Scopus, SCIELO and IME (Spanish medical index) databases from their start dates to February 2014 for original papers about the identification of the relationship between frailty and pre-operative risk evaluation in people aged 65 and over. Review methods We followed criteria of systematic PRISMA guidelines. Two independent reviewe…
A multilocus technique for risk evaluation of patients with neuroblastoma.
2011
Abstract Purpose: Precise and comprehensive analysis of neuroblastoma genetics is essential for accurate risk evaluation and only pangenomic/multilocus approaches fulfill the present-day requirements. We present the establishment and validation of the PCR-based multiplex ligation-dependent probe amplification (MLPA) technique for neuroblastoma. Experimental Design: A neuroblastoma-specific MLPA kit was designed by the SIOP Europe Neuroblastoma Biology Committee in cooperation with MRC-Holland. The contained target sequences cover 19 chromosomal arms and reference loci. Validation was performed by single locus and pangenomic techniques (n = 174). Dilution experiments for determination of min…
Evaluation of caries risk in a young adult population
2007
Introduction: Various caries risk prediction models have been developed in recent years. Cariogram®, a software program that evaluates an individual’s caries risk profile and illustrates it in graphic form, appears to classify patients more correctly than other risk prediction methods. Objectives: The objective of this study was to determine the caries risk of a population by means of the Cariogram® software and examine the relationships between the different variables used by the Cariogram® and the risk of caries determined by this program. Materials and Methods: Data were collected from a sample of 48 young individuals by clinical and radiological examination, saliva sampling and a dietar…
US Food and Drug Administration's Risk Evaluation and Mitigation Strategy for Extended-Release and Long-Acting Opioids Pros and Cons, and a European …
2012
Prescriptions for opioid analgesics to manage moderate-to-severe chronic non-cancer pain have increased markedly over the last decade. An unintentional consequence of greater prescription opioid utilization has been the parallel increase in misuse, abuse and overdose, which are serious risks associated with all opioid analgesics. In response to disturbing rises in prescription opioid abuse, the US Food and Drug Administration (FDA) has proposed the implementation of aggressive Risk Evaluation and Mitigation Strategies (REMS). While REMS could dramatically change the development, release, marketing and prescription of extended-release opioids, questions remain on how these programmes may inf…